THERAPEUTIC POTENTIAL OF BRASSICA OLERACEA EXTRACTS ON LEUKEMIA: AN IN VITRO ANALYSIS

Abstract

Cold water hot water and ethanol extracts  from  Brassica oleracea plant  they were prepared  and  tested  for  their  antioxidant  activity  and efficacy  against leukemia   cells. All   of   the extracts    showed significant antioxidant      activity.   All   the extracts   could kill    the    majority   (50-75%)   of      abnormal cell among    primary   cells    harvested    from   3 patients    with    acute    lympho-blastic   leukemia (ALL) and 3   with acute   myeloid leukemia (AML).    DNA fragmentation patterns were detected within treated cells and  inferred targeted cell death by apoptosis.The metabolites  within  the  ext-racts  may  act  as  tumor  inhibitors  that promote  apoptosis. In  addition  the  plant extracts   may  be  used  to  supplement or  replace established  drugs  treatments .